A massive search and rescue effort is under way in the North Atlantic after a submersible exploring the wreck of the Titanic went missing on Sunday.
The research vessel Polar Prince lost contact with the crew of the Titan sub an hour and 45 minutes into its dive. The US Coast Guard estimated the sub had between 70 and 96 hours of emergency oxygen, as of 17:00 EST (22:00 BST) on Monday.
Tour firm OceanGate said it was exploring all options to get the crew back safely, and government agencies have joined the rescue operation.
Here is what we know so far.
What is the latest on the rescue effort?
The Polar Prince arrived near the location of the Titanic wreck in the Atlantic Ocean on Sunday morning. A Facebook post from Hamish Harding, who was on the Titan, said they expected to start the dive in the submersible at 04:00 local time.
The Boston Coast Guard, which is leading the search operation, said on Twitter that the five person crew "submerged Sunday morning, and the crew of the Polar Prince lost contact with them approximately one hour and 45 minutes into the vessel's dive".
The Titan submersible was thought to be approximately 900 miles (1450km) off the coast of Cape Cod at the time.
The US Coast Guard's Rear Admiral John Mauger said on Monday that it is a challenge to conduct a search in such a remote area.
The search has two aspects, he said. These are a surface search in case the Titan has returned to the ocean's surface but somehow lost communications, and an underwater sonar search.
The Coast Guard has sent two C-130 Hercules aircraft to search for the submersible on the surface of the water, and has been joined by a Canadian C-130, and a P8 aircraft equipped with underwater sonar capability. Sonar buoys are also being deployed in the area.
Rear Adm John Mauger of the US Coast Guard said it would need additional expertise to rescue the vessel if it was found underwater and he was reaching out for help, including to the US Navy and the private sector.
Canada's defence department said that, along with the aircraft, the Canadian coast guard vessel Kopit Hopson was assisting in the search.
Horizon Maritime, which co-owns the Polar Prince, confirmed to the BBC that vessel is helping and a second vessel, the Horizon Arctic, has been sent to the site.
Who was on board?
Among the five people on board the Titan, three people so far have been confirmed - Hamish Harding, a 58-year-old British businessman and explorer, and a Pakistani businessman Shahzada Dawood and his son, Suleman Dawood.
Mr Harding first announced he was joining the team in June last year, and said that the crew on the vessel includes "a couple of legendary explorers, some of which have done over 30 dives to the RMS Titanic since the 1980s".
Mr Harding is the chairman of Action Aviation, an international company which deals with sales and operations in the business aviation industry, based in Dubai, United Arab Emirates.
On Twitter, his firm said on Sunday that "the sub had a successful launch and Hamish is currently diving".
In a statement on Tuesday, the Dawood family said: "Our son Shahzada Dawood and his son, Suleman, had embarked on a journey to visit the remnants of the Titanic in the Atlantic Ocean.
"As of now, contact has been lost with their submersible craft and there is limited information available.
"We are very grateful for the concern being shown by our colleagues and friends and would like to request everyone to pray for their safety while granting the family privacy at this time."
French explorer Paul-Henry Nargeolet is also thought to be on board, according to a Facebook post by Mr Harding before the dive started
And Stockton Rush, chief executive of OceanGate - the firm behind the dive - is also being widely reported to be on the vessel.
What was the sub doing and where is the Titanic?
OceanGate Expeditions charges guests $250,000 (£195,270) for a place on its eight-day expedition to see the famous wreck, which sits 3,800m (12,500ft) beneath the surface at the bottom of the Atlantic.
The site is about 600km (370 miles) off the coast of Newfoundland, and lies in two parts, with the bow and the stern separated by about 800m (2,600ft). A huge debris field surrounds the broken vessel.
A full dive to the wreck, including the descent and ascent, reportedly takes eight hours.
Each expedition lasts eight days, according to OceanGate, and each dive is meant to include a scientific objective, including studying the wreck's decay.
The inaugural dive took place in 2021, according to the company's website.
What might have happened to it?
Submarine expert Prof Alistair Greig from University College London has worked through a number of scenarios for where the missing submersible might be, he told BBC Science Correspondent Pallab Ghosh.
One is that it released a "drop weight" after an emergency, in order to bring it to the surface.
"If there was a power failure and/or communication failure, this might have happened, and the submersible would then be bobbing about on the surface waiting to be found," he said.
Another scenario, he says, is that the hull was compromised resulting in a leak. "Then the prognosis is not good."
If it has gone down to the seabed and can't get back up under its own power, the options - according to Prof Greig - are very limited.
"While the submersible might still be intact, if it is deeper than more than 200m (656ft) there are very few vessels that can get that deep, and certainly not divers. The vehicles designed for navy submarine rescue certainly can't get down to anywhere near the depth of the Titanic."