Uber boss Travis Kalanick has resigned as chief executive after pressure from shareholders, a spokesman has said.
Mr Kalanick will remain on the board of the firm, however, the New York Times reported.
His resignation comes after a review of practices at the firm and scandals including complaints of sexual harassment.
Last week he said he was taking an indefinite leave of absence.
Five major Uber investors demanded Mr Kalanick's immediate resignation in a letter on Tuesday, the newspaper said.
Mr. Kalanick reportedly said: "I love Uber more than anything in the world and at this difficult moment in my personal life I have accepted the investors request to step aside so that Uber can go back to building rather than be distracted with another fight."
Last week Mr Kalanick took an indefinite leave of absence from the firm as part of an effort to create "Uber 2.0".
His leave also comes after the sudden death of his mother in a boating accident.
The ride-hailing company has had a series of recent controversies, including the departure of other high-level executives.
Eric Alexander, the former head of Uber's Asia-Pacific business, left after a report that he had obtained the medical records of a woman who was raped by an Uber driver in 2014.
Mr Alexander reportedly shared them with Mr Kalanick, senior vice-president Emil Michael and others.
Mr Alexander was fired earlier this month, and Mr Michael later left Uber.
This month Uber said it had fired more than 20 staff and took action against others following a review of more than 200 HR complaints that included harassment and bullying.
There has also been a lawsuit from Google's parent company, Alphabet, over alleged theft of trade secrets related to driverless cars.